Blocking malaria transmission
نویسندگان
چکیده
منابع مشابه
Developing transmission-blocking strategies for malaria control
Analysis of the varied developmental pathways exploited by malarial parasites as they pass through their differing life stages can be challenging [1–3], the parasites often adopting mechanisms that differ from the conventional norms of their eukaryotic hosts. It is, however, these unexpected differences that provide fascination and drive to the basic research scientist and simultaneously expose...
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The Plasmodium falciparum and P. berghei genomes each contain three dipeptidyl aminopeptidase (dpap) homologs. dpap1 and -3 are critical for asexual growth, but the role of dpap2, the gametocyte-specific homolog, has not been tested. If DPAPs are essential for transmission as well as asexual growth, then a DPAP inhibitor could be used for treatment and to block transmission. To directly analyze...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2017
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd.2017.184